| c. 430 B.C. |
The Plague of Athens razed the residents of Athens for five years. Science has not confirmed the exact cause of the plague. Among the many possibilities, Typhoid Fever and Ebola have been suggested.
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| 165-180 A.D. |
The Antonine Plague, also known as the Plague of Galen affected Asia Minor, Egypt, Greece, and Italy and thought it may have been Smallpox or Measles.
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| 250-271 A.D. |
The Plague of Cyprian, an unidentified epidemic in the Middle East, Africa and Europe.
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| 541-542 A.D. |
The Plague of Justinian was caused by the Bubonic Plague, and thought to have killed half the population of Europe, afflicting the Byzantine Empire and Mediterranean port cities. Regarded as the first recorded incident of the Bubonic Plague.
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| 1346-1353 |
The Black Death - Bubonic Plague ravaged Europe, Africa, and Asia.
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| 1545-1548 |
The Cocoliztli Epidemic has been identified as a form of viral hemorrhagic fever which attached inhabitants of Mexico and Central America.
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| 1657 |
Measles Outbreak in Boston, Massachusetts
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| 1665-1666 |
Great Plague of London was the last major outbreak of the Black Death's last major outbreak in Great Britain.
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| 1687 |
Measles Outbreak in Boston, Massachusetts
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| 1690 |
Yellow Fever Outbreak in New York.
|
| 1713 |
Measles Outbreak in Boston, Massachusetts
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| 1729 |
Measles Outbreak in Boston, Massachusetts
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| 1732-33 |
Worldwide Influenza
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| 1738 |
Smallpox Outbreak in South Carolina
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| 1739-40 |
Measles Outbreak in Boston, Massachusetts
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| 1747 |
Measles Outbreak in Connecticut, New York, Pennsylvania and South Carolina.
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| 1759 |
Measles Outbreak in North America (areas inhabited by white settlers)
|
| 1761 |
Influenza Outbreak in North America and West Indies
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| 1772 |
Measles Outbreak in North America
|
| 1775 |
Unknown Epidemic in North America Unknown Epidemic - New England hit especially hard
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| 1775-76 |
Worldwide Influenza
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| 1783 |
Dover, Delaware Billous Disorder - extremely fatal
|
| 1788 |
Measles Outbreak in New York and Philadelphia, Pennsylvania
|
| 1793 |
Putrid Fever and Influenza Outbreak in Vermont
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| 1793 |
Influenza Outbreak in Virginia
|
| 1793 |
Yellow Fever Epidemic in Philadelphia, Pennsylvania
|
| 1793 |
Unknown Epidemic in Harrisburg, Pennsylvania
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|
| 1852-1860 |
Third Cholera Pandemic. Considered as the most deadly of the seven cholera pandemics. Originated in India it moved through Asia, Europe, North Africa and North America.
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| 1889-1890 |
The "Asiatic Flu" or "Russian Flu" saw it's first three cases in Bukhara in Central Asia, Athabasca in northwestern Canada, and Greenland.
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| 1910-1911 |
Sixth Cholera Pandemic originated in India and spread to the Middle East, North Africa, Eastern Europe and Russia. Last outbreak of Cholera in America.
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| 1918 |
Influenza Pandemic spread around the world infecting over one-third of the world's population.
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| 1956-1958 |
Asian Flu Pandemic originated in China and spread to Hong Kong, and the United States.
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| 1968 |
Flu Pandemic also known as the "Hong Kong Flu" spread from Hong Kong to Vietnam, The Philippines, India, Australia, Europe and the United States.
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| 2005-2012 |
HIV/AIDS Pandemic was first identified in the Democratic Republic of the Congo in 1976 and has affected individuals around the world.
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